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In this issue:
The New SCCS
Science Today: Scientists Decipher Mechanism behind Antimicrobial "Hole Punchers"
SERA Seeks New Members
Thursday - March 6, 2008 |
The New SCCSScientific Computing and Computing Services (SCCS) has reorganized itself to better serve SLAC's scientific and enterprise computing needs. Customer service becomes a central focus with the creation of two Customer Relations and Project Management groups, one for Scientific Computing (the specialized computing required for science) and one for Enterprise Computing (everything else, including e-mail, web, databases and desktops). These new groups are headed by Steffen Luitz and Bob Cowles, respectively. In addition, the people who deliver the services have been reorganized into four distinct functional groups: Core Services, Departmental Services, Science Applications and Enterprise Applications. Security and Computing Business complete the set of SCCS functions. A look at the new organization chart and its subcharts shows that the new organization has been achieved by asking several key SCCS staff members to wear multiple hats. Their willingness to do so illustrates the enthusiasm and commitment which they, and all of SCCS, want to bring to the department's role in SLAC's future. SCCS is looking forward to working with customers and SLAC management to define the evolving set of services that will serve SLAC best. SCCS representatives will be meeting with other departments in the coming weeks. In addition, a formal framework for steering information technology at SLAC will be defined by management very soon. In the meantime, please help us by letting Steffen Luitz, Bob Cowles or Richard Mount know about your urgent needs and problems. The current status of SCCS services and plans is available online. |
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Scientists Decipher Mechanism behind Antimicrobial "Hole Punchers"The rapid development of bacterial resistance to conventional antibiotics (such as penicillin or vancomycin) has become a major public health concern. Researchers have now deciphered the molecular mechanism behind selective antimicrobial activity for a prototypical class of synthetic compounds. The compounds, which mimic antimicrobial peptides found in biological immune systems, function as molecular "hole punchers," punching holes in the membranes of bacteria, according to University of Illinois researcher Gerard Wong, who led the study. The researchers first synthesized a prototypical class of antimicrobial compounds, then in part used synchrotron small-angle X-ray scattering at SSRL Beamline 4-2 to examine the structures made by the synthetic compounds and cell membranes. Composed of variously shaped lipids, including some that resemble traffic cones, the cell membrane regulates the passage of materials in and out of the cell. In the presence of the antimicrobial molecules, the cone-shaped lipids gather together and curl into barrel-shaped openings that puncture the membrane. Cell death soon follows. The researchers also determined why some compounds punch holes only in bacteria, while others kill everything within reach, including human cells. The work is reported in a paper in the Journal of the American Chemical Society and posted on its website. To learn more about this research see the full scientific highlight. |
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