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In this issue:
Scientists Identify Achilles' Heel of Flu Viruses
SLAC Theorists Named APS Outstanding Reviewers
Italy's Devastating Quake Jolts Gran Sasso Region
Tuesday - April 7, 2009 |
Scientists Identify Achilles' Heel of Flu VirusesScientists have recently identified a family of human antibodies that defend against an unprecedented number of flu virus types, including seasonal flu as well as the deadly H5N1 "bird flu" and 1918 H1N1 "Spanish flu," which killed millions during World War I. A scientific team led by Robert Liddington from the Burnham Institute for Medical Research used the Stanford Synchrotron Radiation Lightsource's Beamline 9-2 to unveil the molecular mechanism by which one of these antibodies, called F10, neutralizes viruses. The results were published online in the February 22 issue of Nature Structural and Molecular Biology. Using X-ray crystallography, the team solved the crystal structure of a potent antibody F10 in complex with the protein hemagglutinin H5, which the virus uses to infect cells. Binding of antibody F10 to hemagglutnin H5 disables a critical step in influenza virus infection. The site at which F10 binds the viral protein is common among many different types of flu viruses, which explains F10's broad spectrum of neutralization against many different types of flu viruses. To learn more about this research, see the full scientific highlight. SLAC Theorists Named
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